6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3; 6PF-2-K/fru-2,6-P2ase 3; PFK/FBPase 3; 6PF-2-K/fru-2,6-P2ase brain/placenta-type isozyme; renal carcinoma antigen NY-REN-56; iPFK-2; includes: 6-phosphofructo-2-kinase; fructose-2,6-bisphosphatase (PFKFB3)

Function

• dual function phosphomonoesterase
• synthesis & degradation of fructose-2,6-bisphosphate
• phosphorylation by AMPK stimulates activity

ATP + D-fructose-6-phosphate -> ADP + D-fructose-2,6-bisphosphate

D-fructose-2,6-bisphosphate + H2O -> D-fructose-6-phosphate + phosphate

Structure

• in the C-terminal section; belongs to the phosphoglycerate mutase family

Alternative splicing

named isoforms=2

Expression

ubiquitous

More general terms

• 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5209
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5209
• OMIM: https://mirror.omim.org/entry/605319
• UniProt: http://www.uniprot.org/uniprot/Q16875.html