6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2; 6PF-2-K/fru-2,6-P2ase 2; PFK/FBPase 2; 6PF-2-K/fru-2,6-P2ase heart-type isozyme; includes: 6-phosphofructo-2-kinase; fructose-2,6-bisphosphatase (PFKFB2)

Function

• dual function phosphomonoesterase
• synthesis & degradation of fructose 2,6-bisphosphate
• phosphorylation results in the activation of kinase activity
• phosphorylation by AMPK stimulates activity

ATP + D-fructose-6-phosphate -> ADP + D-fructose-2,6-bisphosphate

D-fructose 2,6-bisphosphate + H2O -> D-fructose 6-phosphate + phosphate

Structure

• homodimer (putative)
• In the C-terminal section; belongs to the phosphoglycerate mutase family

Alternative splicing

named isoforms=2

Expression

heart

More general terms

• 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5208
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5208
• OMIM: https://mirror.omim.org/entry/171835
• UniProt: http://www.uniprot.org/uniprot/O60825.html