killer cell immunoglobulin-like receptor 3DS1; MHC class I NK cell receptor; natural killer-associated transcript 10; NKAT-10 (KIR3DS1, NKAT10)

Function

• receptor on natural killer (NK) cells for HLA-C alleles
• does not inhibit the activity of NK cells

Structure

• belongs to the immunoglobulin superfamily
• contains 3 Ig-like C2-type domain (immunoglobulin-like)

Compartment

cell membrane

Expression

• expressed in NK cells & T-cell lines but not in B-lymphoblastoid cell lines or in a colon carcinoma cell line

Polymorphism

• the KIR genes are located in a segment of DNA on 19q13.4 in the leukocyte receptor complex that has undergone expansion & contraction over time, probably through unequal crossing-over; thus, KIR haplotypes vary in the number & types of genes, although a few framework loci, such as the gene KIR3DL1, are present on all or nearly all haplotypes.
• KIR3DL1 & KIR3DS1 segregate as alleles of the locus KIR3DL1/3DS1

More general terms

• killer cell immunoglobulin like receptor 3DS (KIR3DS)
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/604946
• UniProt: http://www.uniprot.org/uniprot/Q14943.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3813