ATP-dependent RNA helicase DDX1; DEAD box protein 1; DEAD box protein retinoblastoma; DBP-RB (DDX1)

Function

• helicase
• interacts with MBNL1

Structure

• belongs to the DEAD box helicase family, DDX1 subfamily
• contains 1 B30.2/SPRY domain
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain

Compartment

• cytoplasmic granule
• localized with MBNL1 & TIAL1 & YBX1 in stress granules upon stress

Expression

• highest levels of transcription in retinoblastoma cell lines & in tissues of neuroectodermal origin including retina, brain, & spinal cord

More general terms

• DEAD box ATP-dependent helicase
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1653
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1653
• OMIM: https://mirror.omim.org/entry/601257
• UniProt: http://www.uniprot.org/uniprot/Q92499.html