mitogen-activated protein kinase 6 (extracellular signal regulated kinase 3, ERK3-beta, p97 map kinase, p97MAPK, MAPK6, ERK3, PRKM6)

Function

• phosphorylates microtubule associated protein 2 (MAP2)
• may promote entry into cell cycle
• activated by Thr & Tyr phosphorylation (putative)
• dually phosphorylated on Thr-626 & Tyr-628, which activates the enzyme (putative)

Cofactor: Mg+2 (putative)

Expression

• expressed in skeletal muscle > brain > heart, placenta, lung, liver, pancreas, kidney & skin fibroblasts

More general terms

• extracellular signal regulated kinase [ERK] family protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q16659.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5597
• OMIM: https://mirror.omim.org/entry/602904
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5597