mitogen-activated protein kinase 4 (extracellular signal regulated kinase 3 related, ERK3-alpha, p63-MAPK, p64erk3, p55, p63, p64 MAP kinase, MAPK4, ERK4, PRKM4)
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Function
- phosphorylates microtubule-associated protein 2 (MAP2)
- may promote entry in the cell cycle
Structure
- belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family. MAP kinase subfamily
- contains 1 protein kinase domain
Expression
- high expression in heart & brain
Notes
- mouse homolog may be p55mapk
- not considered by some as bonefide MAP kinase
More general terms
References
- ↑ Pelech SL, Sanghera JS. Mitogen-activated protein kinases: versatile transducers for cell signaling. Trends Biochem Sci. 1992 Jun;17(6):233-8. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1323888
Pelech SL, Sanghera JS. MAP kinases: charting the regulatory pathways. Science. 1992 Sep 4;257(5075):1355-6. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1382311 - ↑ Mohit AA, Martin JH, Miller CA. p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system. Neuron. 1995 Jan;14(1):67-78. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7826642
- ↑ UniProt http://www.uniprot.org/uniprot/P31152.html