alpha-1A adrenergic receptor; alpha 1A-adrenoreceptor; alpha 1A-adrenoceptor; alpha-1C adrenergic receptor; alpha-adrenergic receptor 1c (ADRA1A, ADRA1C)

Function

• alpha-adrenergic receptor
• mediates its action by association with G proteins that activate a phosphatidylinositol- Ca+2 second messenger system
• effect mediated by G(q) & G(11) proteins
• carboxyl-terminal Ser or Thr residues may be phosphorylated

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Alternative splicing

named isoforms=9

Expression

• expressed in heart, brain, liver & prostate
• not expressed in kidney, lung, adrenal, aorta & pituitary
• isoform 4 is the most abundant isoform expressed in prostate; high levels also detected in liver & heart

More general terms

• phosphoprotein
• glycoprotein
• alpha-1 adrenergic receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:148
• OMIM: https://mirror.omim.org/entry/104221
• UniProt: http://www.uniprot.org/uniprot/P35348.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=148