keratin, type 2 cuticular Hb6; type 2 hair keratin Hb6; keratin-86; K86; K2.11 (KRT86, KRTHB6)
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Structure
- heterotetramer of 2 type 1 & 2 type 1 keratins
- belongs to the intermediate filament family
Expression
- synthesis begins slightly higher in the hair shaft than HB1 & HB3 & continues much farther up, ending in the keratogeneous zone
Pathology
- defects in KRT86 are a cause of monilethrix
Genetics
maps to a duplicated region on chromosome 12
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/O43790.html
- ↑ Human intermediate Filament mutation Database http://www.interfil.org
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=KRT86
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3892
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3892
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3892
- OMIM: https://mirror.omim.org/entry/158000
- OMIM: https://mirror.omim.org/entry/601928
- UniProt: http://www.uniprot.org/uniprot/O43790.html
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3892