monilethrix
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Genetics
- autosomal dominant hair disorder
- caused by defects in the KRTHB1, KRTHB3, KRT86 genes
Clinical manifestations
- alopecia
- follicular papules
- affected hairs have uniform elliptical nodes of normal thickness easily breaks
- generally only the scalp is involved
- in severe cases, the secondary sexual hair, eyebrows, eyelashes, and nails may be affected
More general terms
Additional terms
- keratin, type 2 cuticular Hb1; type II hair keratin Hb1; keratin, hair, basic, 1; ghHKb1; ghHb1; keratin-81; K81; K2.9; MLN 137 (KRT81, KRTHB1, MLN137)
- keratin, type II cuticular Hb3; type II hair keratin Hb3; keratin-83; K83; K2.10 (KRT83 KRTHB3)