keratin, type 2 cuticular Hb5; type 2 hair keratin Hb5; keratin-85; K85; K12.12 (KRT85, KRTHB5)

Structure

• type-2 hair keratin
• heterotetramer of 2 type 1 & 2 type 1 keratins
• belongs to the intermediate filament family

Expression

• synthesis occurs immediately above small population of matrix cells at base of hair bulb & trichocytes lining dermal papilla, extends upward through matrix & ends in the lower part of hair shaft cortex

Pathology

• defects in KRT85 are the cause of ectodermal dysplasia pure hair-nail type

Genetics

maps to a duplicated region on chromosome 12

More general terms

• basic hair keratin or type II hair keratin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3891
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3891
• OMIM: https://mirror.omim.org/entry/602032
• OMIM: https://mirror.omim.org/entry/602767
• UniProt: http://www.uniprot.org/uniprot/P78386.html