poly(A) polymerase gamma; PAP-gamma; neo-poly(A) polymerase; neo-PAP; polynucleotide adenylyltransferase gamma; SRP RNA 3'-adenylating enzyme (PAPOLG, PAP2, PAPG)

Function

• post-transcriptional adenylation of 3'-terminal small RNAs including:
  • signal recognition particle (SRP) RNA
  • nuclear 7SK RNA
  • U2 small nuclear RNA
  • ribosomal 5S RNA

Cofactor:

• binds 2 Mg+2
• also active with Mn+2

Structure

belongs to the poly(A) polymerase family

Compartment

nucleus

Expression

• expressed predominantly in testis
• weakly in other tissues
• overexpressed in several tumors

More general terms

• poly[A]polymerase
• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64895
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:64895
• UniProt: http://www.uniprot.org/uniprot/Q9BWT3.html