beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase-I, galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1, GlcAT-I, UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase, GlcUAT-P, B3GAT1)

Function

• role in the biosynthesis of L2/HNK-1 carbohydrate epitopes on glycoproteins
• role in glycosaminoglycan biosynthesis
• substrates include asialo-orosomucoid (ASOR), asialo-fetuin, & asialo-neural cell adhesion molecule
• requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin & lignoceroyl-sphingomyelin
• activity was demonstrated only for sphingomyelin with a saturated fatty acid & not for that with an unsaturated fatty acid, regardless of the length of the acyl group (putative)
• protein modification, protein glycosylation

Cofactor: Mn+2

Structure

• homodimer (putative)
• belongs to the glycosyltransferase 43 family

Compartment

Golgi

Expression

mainly expressed in the brain

More general terms

• UDP-glucuronosyltransferase (UDPGT)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9P2W7.html
• OMIM: https://mirror.omim.org/entry/151290