fucosyltransferase-2; galactoside 2-L-fucosyl transferase 2; secretor blood group alpha-2-fucosyltransferase (FUT2)
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Function
- creates blood group H antigen
- protein modification; protein glycosylation
Structure
belongs to the glycosyltransferase 11 family
Compartment
Alternative initiation
named isoforms=2
Expression
- small intestine, colon & lung
- FUT1 & FUT2 encode galactoside 2-L-fucosyltransferase
- they are expressed in a tissue-specific manner with expression restricted to cells of mesodermal or endodermal origin respectively
Polymorphism
- 3 alleles have been identified in Japanese: Se1, Se2, Sej
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q10981.html
- ↑ BGMUT; Note: Blood group antigen gene mutation database http://www.ncbi.nlm.nih.gov/projects/mhc/xslcgi.fcgi?cmd=bgmut/systems_info&system=hh
- ↑ GGDB; Note: Glycogene database http://riodb.ibase.aist.go.jp/rcmg/ggdb/homolog?cat=symbol&symbol=FUT2
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/fut2/ Functional Glycomics gateway - GTase Note: fucosyltransferase 2 http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_599