2',5'-phosphodiesterase; 2-PDE; 2'-PDE (PDE12)

Function

• 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system
• this enzyme degraded triphosphorylated 2-5A to produce AMP & ATP
• also cleaves 3',5'-phosphodiester bond of oligoadenylates
• plays a role as a negative regulator of the 2- 5A system that is one of the major pathways for antiviral & antitumor functions induced by interferons (IFNs)
• suppression induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system

Structure

belongs to the CCR4/nocturin family

Alternative splicing

named isoforms=3

Expression

ubiquitous

More general terms

• phosphodiesterase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2016
• UniProt: http://www.uniprot.org/uniprot/Q6L8Q7.html