phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; inositol polyphosphate-5-phosphatase J (INPP5J, PIB5PA, PIPP)

Function

• inositol-5-phosphatase
• converts
  • inositol-1,4,5-trisphosphate to inositol-1,4-bisphosphate
• in vitro, converts
  • phosphatidylinositol-4,5-bisphosphate to phosphatidylinositol-4-phosphate
  • inositol-1,3,4,5-tetrakisphosphate to inositol-1,3,4-trisphosphate
• may be involved in modulating inositol & phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles

inositol-1,4,5-trisphosphate + H2O =
              inositol-1,4-bisphosphate + phosphate

inositol-1,3,4,5-tetrakisphosphate + H2O =
              inositol-1,3,4-triphosphate + phosphate

phosphatidylinositol-4,5-bisphosphate + H2O =
          phosphatidylinositol-4-phosphate + phosphate

Structure

• the 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein
• belongs to the inositol-1,4,5-trisphosphate-5-phosphatase type 2 family

Compartment

• cytoplasm (putative)
• predominantly localized to membrane ruffles (putative)

Alternative splicing

named isoforms=3

More general terms

• phosphomonoesterase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27124
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27124
• OMIM: https://mirror.omim.org/entry/606481
• UniProt: http://www.uniprot.org/uniprot/Q15735.html