bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; diadenosine 5',5'-P1,P4-tetraphosphate asymmetrical hydrolase; Ap4A hydrolase; Ap4Aase; diadenosine tetraphosphatase; nucleoside diphosphate-linked moiety X motif 2; Nudix motif 2 (NUDT2, APAH1)

Function

• asymmetrically hydrolyzes Ap4A to yield AMP & ATP
• role in maintaining homeostasis

P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H2O = GTP + GMP

Cofactor: divalent ions (putative)

Structure

• belongs to the Nudix hydrolase family
• contains 1 nudix hydrolase domain

More general terms

• tetraphosphatase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=318
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:318
• OMIM: https://mirror.omim.org/entry/602852
• UniProt: http://www.uniprot.org/uniprot/P50583.html