alpha mannosidase-2; ER/GOLGI alpha-mannosidase (MAN2A1, MANA2)

Function

• catalyzes 1st committed step in the biosynthesis of complex N-glycans
• controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway
• protein modification; protein glycosylation
• hydrolysis of the terminal (1->3)- & (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide man(5)(GlcNAc)(3)

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

• homodimer, disulfide-linked (putative)
• glycosylated (putative)
• belongs to the glycosyl hydrolase 38 family

Compartment

• Golgi membrane

More general terms

• alpha-mannosidase (MANA)
• glycoprotein
• membrane protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4124
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4124
• OMIM: https://mirror.omim.org/entry/154582
• UniProt: http://www.uniprot.org/uniprot/Q16706.html