heme oxygenase-2 (HMOX2, HO-2)
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Function
- in association with cyt P450 reductase & bilirubin reductase, cleaves heme to form bilirubin, CO & Fe+2
- electrons donated by cyt P450 reductase
- biliverdin reductase rapidly reduces biliverdin to bilirubin
- could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter
heme oxygenase
cyt P450 reductase
heme[Fe+2] + O2 ------------------> biliverdin + CO + Fe+2
+ NADPH + H+ + NADP+ + H2O
biliverdin reductase biliverdin ------------------> bilirubin + NADP+ + NADPH + H+
Structure
- belongs to the heme oxygenase family
- contains 2 HRM (heme regulatory motif) repeats
Compartment
Expression
- constitutively expressed form of heme oxygenase
- major form of heme oxygenase found in brain
More general terms
References
- ↑ Snyder SH. Nitric oxide: first in a new class of neurotransmitters. Science. 1992 Jul 24;257(5069):494-6. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1353273
- ↑ Smith MA, Kutty RK, Richey PL, Yan SD, Stern D, Chader GJ, Wiggert B, Petersen RB, Perry G. Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease. Am J Pathol. 1994 Jul;145(1):42-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8030754
- ↑ Sedlak TW, Snyder SH. Messenger molecules & cell death: therapeutic implications. JAMA. 2006 Jan 4;295(1):81-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16391220
- ↑ UniProt http://www.uniprot.org/uniprot/P30519.html