ATP-dependent RNA helicase DHX8; DEAH box protein 8; RNA helicase HRH1 (DHX8 DDX8)

Function

• facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome
• identified in the spliceosome C complex
• interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation

Structure

• the RS domain confers a nuclear localization signal, & appears to facilitate the interaction with the spliceosome
• belongs to the DEAD box helicase family, DEAH subfamily, DDX8/PRP22 sub-subfamily
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain
• contains 1 S1 motif domain

Compartment

nucleus

More general terms

• DEAH box ATP-dependent helicase
• phosphoprotein

Component of

• spliceosome
• C

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1659
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1659
• OMIM: https://mirror.omim.org/entry/600396
• UniProt: http://www.uniprot.org/uniprot/Q14562.html