poly [ADP-ribose] polymerase 10; PARP-10; ADP-ribosyltransferase diphtheria toxin-like 10; ARTD10 (PARP10)

Function

• cell proliferation
• maintenance of cell cycle progression
• poly [ADP-ribose] polymerase
• interacts with MYC
• phosphorylation by CDK2 stimulates PARP10
  • phosphorylation through late-G1 to S phase, & from prometaphase to cytokinesis in nucleolar organizing regions
  • phosphorylation is suppressed in growth-arrested cells

Structure

contains 1 PARP catalytic domain

Compartment

• nucleus, nucleolus, cytoplasm
• shuttles between nucleus & cytoplasm
• some concentrates in the nucleolus during late G1/S phase

Expression

• expressed in spleen, thymus > liver, kidney, pancreas, prostate, testis, ovary, intestine, leukocytes > heart, brain, placenta, lung, skeletal muscle, colon

More general terms

• NAD+ ADP-ribosyltransferase or poly ADP-ribose polymerase
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84875
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84875
• OMIM: https://mirror.omim.org/entry/609564
• UniProt: http://www.uniprot.org/uniprot/Q53GL7.html