poly [ADP-ribose] polymerase 4; PARP-4; 193 kD vault protein; PARP-related/IalphaI-related H5/proline-rich; PH5P; vault poly(ADP-ribose) polymerase; VPARP (PARP4, ADPRTL1, KIAA0177, PARPL)

Introduction

Also see poly[ADP-ribose]polymerase

Function

• component of the vault ribonucleoprotein particle
• binds to MVP. associates with TEP1

Structure

• contains 1 BRCT domain
• contains 1 PARP alpha-helical domain
• contains 1 PARP catalytic domain
• contains 1 VIT domain
• contains 1 VWFA domain

Compartment

• cytoplasm, nucleus, cytoskeleton, spindle
• found in the nucleus
• associates with mitotic spindles

Expression

• widely expressed
• highest levels are in the kidney
• also detected in heart, placenta, lung, liver, skeletal muscle, spleen, leukocytes & pancreas

More general terms

• NAD+ ADP-ribosyltransferase or poly ADP-ribose polymerase

Additional terms

• poly(ADP-ribose)glycohydrolase (pARG)

Component of

• vault ribonucleoprotein complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=143
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:143
• OMIM: https://mirror.omim.org/entry/607519
• UniProt: http://www.uniprot.org/uniprot/Q9UKK3.html