testicular acid phosphatase (ACPT)

Function

• dephosphorylates receptor tyrosine-protein kinase erbB-4 & inhibits the ligand-induced proteolytic cleavage

Structure

• homodimer
• belongs to the histidine acid phosphatase family

Compartment

membrane

Alternative splicing

named isoforms=3

Expression

• expressed mainly in the testis
• also expressed in brain, enriched at the post-synaptic sites
• expressed at lower levels in the trachea, prostate, bone marrow, spinal cord, colon, fetal brain, heart, thymus, fetal liver, spleen, leukocytes, ovary, small intestine, pancreas, skeletal muscle
• isoform 3 is expressed in testis, trachea, prostate, bone marrow
• up-regulated by mibolerone (a synthetic androgen) & dihydrotestosterone (DHT)
• down-regulated by estrogen & progestin

Pathology

• expression is significantly lower in testicular cancer than in normal testicular tissues

More general terms

• acid phosphatase

Additional terms

• testis

Database

• OMIM: https://mirror.omim.org/entry/606362
• UniProt: http://www.uniprot.org/uniprot/Q9BZG2.html