ATPase ASNA1; arsenical pump-driving ATPase; arsenite-stimulated ATPase; transmembrane domain recognition complex 40 kD ATPase subunit; hARSA-I; hASNA-I (ASNA1, ARSA, TRC40)

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Function

ATPase required for the post-translational delivery of tail-anchored proteins to the endoplasmic reticulum
recognizes & selectively binds the transmembrane domain of tail-anchored proteins in the cytosol
this complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion
this process is regulated by ATP binding & hydrolysis
ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized tail-anchored membrane proteins
ATP hydolysis is required for insertion
subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, & returning it to the cytosol to initiate a new round of targeting (putative)
may be involved in insulin signaling
interacts with SERP1 & SEC61B (putative
interacts with WRB
component of a transmembrane domain recognition complex

previously described as an anion-transporting ATPase, catalyzing extrusion of arsenite

ATP + H2O + arsenite(In)  <--> ADP + phosphate + arsenite(Out)