cAMP-specific 3',5'-cyclic phosphodiesterase 7B (PDE7B)

Function

• hydrolyzes the second messenger cAMP
• may be involved in the control of cAMP-mediated neural activity & cAMP metabolism in the brain
• purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1

adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate

Cofactor:

• binds 2 divalent metal cations per subunit
• site 1 may preferentially bind Zn+2
• site 2 has a preference for Mg+2 &/or Mn+2 (putative)

Inhibition:

• inhibited by dipyridamole, IBMX & SCH 51866
• insensitive to zaprinast, rolipram, & milrinone

Structure

• composed of a C-terminal catalytic domain containing two putative divalent metal sites & an N-terminal regulatory domain
• belongs to the cyclic nucleotide phosphodiesterase family, PDE7 subfamily

Expression

• highly expressed in brain
• also expressed in heart, liver, skeletal muscle & pancreas

More general terms

• phosphodiesterase 7

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27115
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27115
• OMIM: https://mirror.omim.org/entry/604645
• UniProt: http://www.uniprot.org/uniprot/Q9NP56.html