cGMP-inhibited 3',5'-cyclic phosphodiesterase A; cyclic GMP-inhibited phosphodiesterase A; CGI-PDE A (PDE3A)

Function

• cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP & cGMP

nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

Cofactor:

• binds 2 divalent metal cations per subunit
• site 1 may preferentially bind Zn+2
• site 2 has a preference for Mg+2 &/or Mn+2 (putative)

Inhibition:

• inhibited by cGMP

Structure

• belongs to the cyclic nucleotide phosphodiesterase family, PDE3 subfamily

Compartment

membrane

More general terms

• phosphodiesterase 3; cGMP inhibited phosphodiesterase (PDE3)
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5139
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5139
• OMIM: https://mirror.omim.org/entry/123805
• UniProt: http://www.uniprot.org/uniprot/Q14432.html