Ca+2/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; Cam-PDE 1C; hCam-3 (PDE1C)

Function

• cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP & cGMP
• high affinity for both cAMP & cGMP
• activated by the binding of calmodulin in the presence of Ca+2

nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

Cofactor:

• binds 2 divalent metal cations per subunit
• site 1 may preferentially bind Zn+2
• site 2 has a preference for Mg+2 &/or Mn+2 (putative)

Structure

• homodimer (putative)
• belongs to the cyclic nucleotide phosphodiesterase family, PDE1 subfamily

Alternative splicing

• named isoforms=2
• additional isoforms seem to exist

Expression

• expressed in brain & heart

More general terms

• phosphodiesterase 1

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5137
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5137
• OMIM: https://mirror.omim.org/entry/602987
• UniProt: http://www.uniprot.org/uniprot/Q14123.html