5'-nucleotidase domain-containing protein 3 (Grp94-neighboring nucleotidase, NT5DC3, GNN, TU12B1-TY)

Introduction

Cofactor: binds 1 Mg+2 per subunit (putative)

Structure

belongs to the 5'(3')-deoxyribonucleotidase family

Alternative splicing

named isoforms=2

Expression

• expressed in brain, placenta, skeletal muscle, pancreas, testis, uterus, & small intestine

Pathology

• diminished function may contribute to the development &/or progression of pancreatic cancer
• expression was increased in 2 acute myeloid leukemia clusters

More general terms

• deoxyribonuclease (DNase)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5155
• UniProt: http://www.uniprot.org/uniprot/Q86UY8.html