myosin-3a (MYO3A)

Function

• probable actin-based motor with a protein kinase activity
• probably plays a role in vision & hearing

Structure

• in the N-terminal section; belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family
• contains 3 IQ domains
• contains 1 myosin head-like domain
• contains 1 protein kinase domain

Compartment

cytoplasm, cytoskeleton

Expression

• strongest expression in retina, retinal pigment epithelial cells, cochlea & pancreas

Pathology

• defects in MYO3A are the cause of deafness autosomal recessive type 30

More general terms

• unconventional myosin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=53904
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:53904
• OMIM: https://mirror.omim.org/entry/606808
• OMIM: https://mirror.omim.org/entry/607101
• UniProt: http://www.uniprot.org/uniprot/Q8NEV4.html