nuclease EXOG, mitochondrial; endonuclease G-like 1; endo G-like 1 (EXOG, ENDOGL1, ENDOGL2, ENGL)

Function

-endonuclease/exonuclease with nicking activity towards supercoiled DNA

• preference for single stranded DNA
• 5'-3' exonuclease activity

Cofactor:

• divalent metal cation
• the active site contains 1 hydrated divalent metal cation that has only 1 direct interaction with the protein

Structure

• homodimer
• belongs to the DNA/RNA non-specific endonuclease family

Compartment

mitochondrial inner membrane

Alternative splicing

• named isoforms=4
• at least one isoform is probably inactive, since it lacks the active site

Expression

ubiquitous

More general terms

• endodeoxyribonuclease
• endoribonuclease
• mitochondrial protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9941
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9941
• OMIM: https://mirror.omim.org/entry/604051
• UniProt: http://www.uniprot.org/uniprot/Q9Y2C4.html