hemoglobin H disease

Clinical manifestations

• onset of symptoms may be in childhood or as an adult (in milder cases)
• hemolytic anemia
• marked splenomegaly

Laboratory

• complete blood count
  • hemoglobin 6-10 g/dL
  • MCV 60-70 fL (microcytosis)
• peripheral smear
  • target cells
  • Heinz bodies
• reticulocytes are increased
• hemoglobin electrophoresis: Hgb A (70-95%), Hgb H (5-30%)

More general terms

• alpha thalassemia

Patient information

hemoglobin H disease patient information