regulatory solute carrier protein family 1 member 1 (transporter regulator RS1, hRS1, RSC1A1)

Function

• mediates transcriptional & post-transcriptional regulation of SLC5A1
• inhibits a dynamin & PKC-dependent exocytotic pathway of SLC5A1
• involved in transcriptional regulation of SLC22A2
• exhibits glucose-dependent, short-term inhibition of SLC5A1 & SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network

Structure

• tripeptides QCP & QSP mediate post-transcriptional down-regulation of SLC5A1 at the trans-Golgi network
• they inhibit a monosaccharide-dependent exocytotic pathway of SLC5A1 contains 1 UBA domain

Compartment

• cell membrane, nucleus, Golgi, trans-Golgi network
• localizes at the inner side of the plasma membrane

Expression

expressed in small intestine, kidney & brain

More general terms

• uncharacterized protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6248
• OMIM: https://mirror.omim.org/entry/601966
• UniProt: http://www.uniprot.org/uniprot/Q92681.html