protein KIAA1546 (KIAA1546, TET2, Nbla00191)

Function

• plays a critical role in DNA methylation and hematopoiesis

Alternative splicing

named isoforms=3

Pathology

• somatic mutations in the TET2 gene are frequently observed in
  • myelodysplastic syndromes
  • myeloproliferative neoplasms
    • essential thrombocythemia
    • polycythemia vera
  • primary myelofibrosis
  • acute myeloid leukemia
  • chronic myelomonocytic leukemia

More general terms

• uncharacterized protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5479
• UniProt: http://www.uniprot.org/uniprot/Q6N021.html