invasion-inhibitory protein 45; IGFBP2-binding protein (IIP45, MIIP)

Function

• inhibibits glioma cells invasion & down-regulates adhesion- & motility-associated genes such as NFKB2 & ICAM1
• exhibits opposing effects to IGFBP2 on cell invasion
• interacts with IGFBP2
• isoform 2 is degraded by the ubiquitin-proteasome pathway

Alternative splicing

named isoforms=2

Expression

• ubiquitous
• isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level
• up-regulated by IGFBP2

Pathology

• isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression
• on the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in glioma cells

More general terms

• uncharacterized protein

Database

• OMIM: https://mirror.omim.org/entry/608772
• UniProt: http://www.uniprot.org/uniprot/Q5JXC2.html