X-ray radiation resistance-associated protein 1 (XRRA1)

Function

• may be involved in the response of cells to X-ray radiation

Structure

contains 6 LRR repeats (leucine-rich repeats)

Compartment

cytoplasm. nucleus

Alternative splicing

named isoforms=4 gene model based on mouse cDNA data

Expression

• expressed predominantly in testis
• expressed in prostate & ovary > other tissues including peripheral blood leukocytes, spleen, thymus, small intestine & colon

induced by X-ray radiation immediately after exposure & is then down-regulated two-fold in an X-ray radiation-resistant cell clone. responds differently to X-ray radiation in clones of varying radiation responses

Pathology

• expressed in neuroblastoma, glioma, breast cancer, lung cancer, leukemia, renal cell carcinoma, ovarian cancer, prostate cancer, & colorectal cancer cell lines

More general terms

• uncharacterized protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6P2D8.html