fibronectin type III & SPRY domain-containing protein 1 (microtubule-associated protein GLFND, MID1-related protein 1, FSD1, GLFND, MIR1, VLP27)
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Function
- may be involved in microtubule organization & stabilization
- oligomerization is required for binding to microtubules
Structure
- B30.2 box contains a microtubule-binding site
- contains 1 B30.2/SPRY domain
- contains 1 COS domain
- contains 1 fibronectin F3 module
Compartment
- centrosome, nucleus, cytoplasm
- cell-cycle-dependent association with the centrosome
- colocalizes with a subpopulation of microtubules
- does not associate with microtubules during mitosis but reassociates with microtubules during cytokinesis
- localizes to the central portions of a small subset of microtubules in interphase cells & a subpopulation of microtubules in the cleavage furrow
- not present in the mitotic spindle
Expression
- highly expressed in brain tissues, including cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe & putamen
- lower expression in spinal cord