Protein zwilch homolog (hZwilch, ZWILCH)

Function

• component of the mitotic checkpoint
• required for the assembly of the dynein-dynactin & MAD1-MAD2 complexes onto kinetochores
• component of the RZZ complex composed of KNTC1/ROD, ZW10 & ZWILCH

Structure

belongs to the ZWILCH family

Compartment

kinetochore (probable)

Alternative splicing

named isoforms=2

Pathology

• ZWILCH gene is deleted in a patient suffering from colorectal cancer with chromosomal instability

More general terms

• uncharacterized protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5505
• UniProt: http://www.uniprot.org/uniprot/Q9H900.html