FGFR1 oncogene partner 2 (FGFR1OP2)

Function

• may be involved in wound healing pathway

Structure

belongs to the SIKE family

Compartment

cytoplasm (putative)

Alternative splicing

named isoforms=3

Expression

expressed in bone marrow, spleen & thymus

Pathology

• chromosomal insertion ins(12;8)(p11;p11p22) involving FGFR1OP2 with FGFR1 may be a cause of stem cell myeloproliferative disorder (MPD)
• fusion protein FGFR1OP2-FGFR1 may exhibit constitutive kinase activity & be responsible for the transforming activity

More general terms

• uncharacterized protein

Database

• OMIM: https://mirror.omim.org/entry/608858
• UniProt: http://www.uniprot.org/uniprot/Q9NVK5.html