syncollin (insulin synthesis-associated protein 1, SYCN, INSSA1, SYL)

Function

• role in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other
• may have a pore-forming activity on membranes & regulate exocytosis in other exocrine tissues (putative)
• interacts with GP2 (putative)

Structure

• monomer & homooligomer, most probably hexameric
• contains intrachain disulfide bonds (putative)

Compartment

• cytoplasmic vesicle, secretory vesicle
• membrane, peripheral membrane protein, lumenal side
• cytoplasmic vesicle, secretory vesicle. lumenal side
• localizes to zymogen granules
• associated with lipid rafts (cholesterol-dependent) (putative)

More general terms

• uncharacterized protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q0VAF6.html