spliceosome E complex

Function

• 1st complex of spliceosome assembly
• ATP-independent complex that commits hnRNA into the splicing pathway
• U1 snRNP binds to 5' end splice site of hnRNA & recruits other factors to form the 'E complex'
• U2 snRNP is recruited to the branch region of a splice site through interactions with the 'E complex' component U2AF & possibly U1 snRNP

Structure

• consist of hnRNA, U1 snRNP, U2AF

Additional terms

• spliceosome