Menetrier's disease
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Etiology
unknown
Epidemiology
- rare, acquired
- adult & pediatric forms[3]
Pathology
- gastric mucosal hypertrophy
- pseudopolypoid, thickened rugal folds
- protein-losing gastropathy
- hypoalbuminemia
- gastric pit region (foveolar) hyperplasia
Clinical manifestations
- abdominal pain, especially after eating
- nausea/vomiting
- hematemesis
Laboratory
- serum albumin low
- urinalysis: no proteinuria
- liver function tests unremarkable
Diagnostic procedures
Radiology
- CT of abdomen
- Scintigraphy with technetium-99m-labeled albumin reveals gastrointestinal protein loss
Management
- proton pump inhibitor or other antacid
- high-protein diet
- partial gastrectomy may be necessary to control symptoms
- case presentation in 5 year old boy with resolution of symptoms after 4 months
More general terms
References
- ↑ Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996, pg 327
- ↑ Akita C, Saikawa Y. (images) Gastric Gyri - Pediatric Menetrier's Disease. N Engl J Med 2017; 376:774February 23, 2017 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28225680 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMicm1605473
- ↑ 3.0 3.1 NIDDK: Menetrier's Disease https://www.niddk.nih.gov/health-information/digestive-diseases/menetriers-disease