march hemoglobinuria; runner's anemia; exercise-induced hemolysis
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Pathology
- mechanical trauma to erythrocytes in the microvasculature during strenuous exercise
- hemoglobinuria due to prolonged & intense exertion
- loss of iron through the urine & GI treact
Clinical manifestations
- pain in back & thighs
- dark urine
Laboratory
- urinalysis: hemoglobin in urine without red cells
- complete blood count with peripheral smear
- platelet count normal
- no erythrocyte fragments in peripheral smear
- anemia, microcytosis
- iron studies consistent with iron-deficiency anemia
- low serum ferritin
- serum LDH elevated consistent with hemolysis
- serum creatine kinase normal or minimally elevated
More general terms
References
- ↑ DeGowin & DeGowin's Diagnostic Examination, 6th edition, RL DeGowin (ed), McGraw Hill, NY 1994, pg 893
- ↑ Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 668
- ↑ 3.0 3.1 Dang CV Runner's anemia. JAMA. 2001 Aug 8;286(6):714-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11495622
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015