diffuse cutaneous (pseudoxanthomatous) mastocytosis (DCM)

Introduction

A generalized cutaneous mastocytosis.

Clinical manifestations

• yellowish, thickened appearance of skin
• lesions smooth with scattered areas of elevation, resembling leather
• exaggerated skin folds, especially in axilla & groin
• large bullae may occur spontaneously or following trauma
• may present as erythroderma

Differential diagnosis

• Histiocytosis
• secondary syphilis
• sarcoid
• histiocytoma
• non-X histiocytosis

More general terms

• mastocytosis