rhinoscleroma
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Introduction
Gram negative rod infection of the nose extending to the larynx.
Etiology
Epidemiology
- endemic in Central & South America, south & central Europe, Egypt & southwest Asia
Pathology
- tissue hematoxylin & eosin stain
- foamy macrophages with intracytoplasmic bacilli[2]
- plasma cells with Russell bodies[2]
- Warthin-Starry stain
- intracellular Klebsiella rhinoscleromatis
Clinical manifestations
- mass growing in the central region of face, involving nose & upper lip (case report)[2]
- bilateral nostril obliteration
- palate infiltration
- loss of upper teeth
Laboratory
- culture of tisuue fragments for Klebsiella
Differential diagnosis
- other conditions that cause central facial destruction include:
- giant-cell carcinoma
- natural killer T-cell lymphoma
- granulomatosis with polyangiitis
- tuberculosis
- leprosy
- leishmaniasis
- blastomycosis
- cryptococcosis
- syphilis
Management
- ciprofloxacin
- plastic surgery referral
More general terms
References
- ↑ Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996, pg 108
- ↑ Jump up to: 2.0 2.1 2.2 2.3 Castanedo Cazares JP1, Martinez Rosales KI Images in Clinical Medicine. Rhinoscleroma. N Engl J Med. 2015 Jun 18;372(25):e33 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26083225 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMicm1411602