phospholipid flippase

Introduction

Energy-dependent 'flip' of phospholipid from inner to outer leaflet of the endoplasmic reticulum &/or plasma membrane. Members of ATP-binding cassette transporter family are putative flippases; however ref 2 suggest true flippase(s) have not yet been identified.

More general terms

• biochemistry

More specific terms

• P-glycoprotein 1 (PGY1, multidrug resistance protein 1, MDR1, gp170, ATP-binding cassette subfamily B member 1, ABCB1)
• P-glycoprotein 3 (PGY3, multidrug resistance protein 3, MDR3, ATP-binding cassette subfamily B member 4, ABC4)
• retinal-specific ATP-binding cassette transporter; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Stargardt disease protein (ABCA4 ABCR)