1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-2; phosphoinositide phospholipase C-eta-2; phosphoinositide phospholipase C-like 4; PLC-L4; phospholipase C-like protein 4; phospholipase C-eta-2; PLC-eta2 (PLCH2, KIAA0450, PLCL4)

Function

• phospholipase C
• formation of second messengers diacylglycerol & inositol 1,4,5-trisphosphate (IP3)
• activity very sensitive to Ca+2
• may be important for formation & maintenance of the neuronal network in the postnatal brain

1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate + H2O = 1D-myo-inositol-1,4,5-trisphosphate + diacylglycerol

Cofactor: Ca+2 (putative)

Structure

• contains 1 C2 domain
• contains 2 EF-hand domains
• contains 1 PH domain
• contains 1 PI-PLC X-box domain
• contains 1 PI-PLC Y-box domain

Compartment

• cytoplasm, cell membrane
• localized predominantly at the plasma membrane (putative)

Alternative splicing

named isoforms=5

Expression

expressed in retina & kidney

More general terms

• phospholipase C

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9651
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9651
• OMIM: https://mirror.omim.org/entry/612836
• UniProt: http://www.uniprot.org/uniprot/O75038.html