1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-1 (phospholipase C-eta-1, PLC-eta-1, phospholipase C- like protein 3, PLC-L3, PLCH1, KIAA1069, PLCL3)
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Function
- production of the second messenger molecules diacylglycerol (DAG) & inositol 1,4,5-trisphosphate (IP3) is mediated by Ca+2-activated phosphatidylinositol-specific phospholipase C enzymes
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O <--> 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Structure
- contains 1 C2 domain
- contains 2 EF-hand domains
- contains 1 PH domain
- contains 1 PI-PLC X-box domain
- contains 1 PI-PLC Y-box domain
Compartment
cytoplasm. membrane
Alternative splicing
named isoforms=4
Expression
- expressed in brain & to a lower extent in lung
- in brain, it is found in cerebrum, cerebellum & spinal cord