primary prevention project (PPP)

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Introduction

Low dose aspirin (100 mg QD) significantly reduced cardiovascular death (0.8% vs. 1.4%, relative risk 0.56), but was associated with a higher risk of severe bleeding (1.1% vs 0.3%) vs placebo. Vitamin E (300 mg QD) was of no benefit.

More general terms

References

  1. Journal Watch 21(6):45, 2001 Lancet 357:84, 2001