steroid psychosis

^[1]^[2]

Clinical manifestations

bipolar symptoms
steroid psychosis severe in 6%, mild-moderate in 28%^[1]
begins 7-10 days after starting
dosage is directly related to the incidence of adverse effects^[1]
- 26% incidence with 120 mg/day of methylprednisolone for 8 days^[1]
- 1.3% incidence with < 40 mg prednisone/day
- 4.6% incidence with 41-80 mg prednisone/day
- 18% incidence with > 80 mg prednisone/day
case report of steroid psychosis 1 week after 7 days of IV dexamethasone 6 mg/day^[2]

↑ ^1.0 ^1.1 ^1.2 ^1.3 Warrington TP, Bostwick JM. Psychiatric adverse effects of corticosteroids. Mayo Clin Proc. 2006 Oct;81(10):1361-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17036562 Review
↑ ^2.0 ^2.1 Kazi SE, Hoque S. Acute Psychosis Following Corticosteroid Administration Cureus. 2021 Sep 19;13(9):e18093 PMID: https://www.ncbi.nlm.nih.gov/pubmed/34692307 Free PMC article