scrapie

Introduction

Prion disease in sheep & goats.

Pathology

• presence of differentiated B-lymphocytes is important for invasion of the nervous system after intraperitoneal innoculation of mice
• after innoculation into limbs, scrapie agent travels along peripheral nerves to central nervous system

More general terms

• animal spongiform encephalopathy

Additional terms

• CD230 or major prion protein (PrP)
• transmissible spongiform encephalopathy (prion disease)