Wolfram syndrome; diabetes insipidus & mellitus with optic atrophy & deafness syndrome (DIDMOAD)

Epidemiology

rare

Genetics

• autosomal recessive
• associated with mutations in gene for wolframin

Clinical manifestations

• juvenile onset
• diabetes insipidus
• diabetes mellitus
• optic atrophy
• deafness
• various neurological symptoms

More general terms

• genetic syndrome (multisystem disorder)
• genetic disease of the endocrine system

Additional terms

• Wolfram syndrome 2
• Wolframin (WFS1)

Database

• OMIM: https://mirror.omim.org/entry/606201
• OMIM: https://mirror.omim.org/entry/222300